SINCE World war 2, medical science has progressed into a stage where competitive medications are around for treat the identical ailment in various people. This is simply not just about brands (that is a trade issue) but generic drugs (that is a scientific issue). In this report, we shall glance at the various factors that decide your selection of a certain drug.
Safety: These sub-criteria have to be considered under the criterion of safety:
* Acute therapeutic index: If your patient’s condition is acute, how effective is a particular drug regardless of whether it’s certain side-effects as long as the acuteness in the condition is lowered? Example: narcotic pain-killers are amazing in healing pain but feature the opportunity side-effect of addiction.
* Long-term safety: directory could be safe in short-term treatment, but exactly how safe it really is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but could have undesirable effects in the event of prolonged use.
* Drug-drug interaction risk: Medicine is chemicals, and lots of chemicals respond to develop a different chemical, that have an effect that may harm the patient or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to create a new condition that warrants separate treatment.
Drug-drug interaction risk is of two kinds:
· Pharmacokinetic: In this kind of drug-drug interaction, two drugs, independent of the other person, have certain effects on a single or even more body processes (e.g., metabolism) that affects the performance in the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) depends on for the metabolism. This makes an increase in the side-effects of Lexapro.
· Pharmacodynamic: Here, a couple of drugs actually create the same effect on the identical organ, thus improving the total, added effect. Example: Lexapro has certain side-effects such as drowsiness and fatigue. Darvocet-N also acts similarly on the brain. Thus, the side-effects of the two medicines are more serious.
Tolerability: A medication could be effective although not tolerable by all patients. Example: Allergies to specific drugs in a few people. Short-term and long-term tolerability need to be taken into consideration. Efficacy: A medication isn’t equally efficient at all patients. For instance, some patients with depression or anxiety attacks experience respite from escitalopram, but there are numerous who don’t, who therefore need to be prescribed a different anti-depressant. The pace of onset of therapeutic action is a factor to be looked at too.
Cost: Cost does not mean the cost of purchase of a certain medicine alone. It must also cover the cost of management of a complication that may arise from utilizing a different drug. Example: In the person who insists on taking alcohol but must be treated for depression is normally administered an SSRI drug as these drugs don’t potentiate the results of alcohol, whereas another number of anti-depressants (such as tricyclics) may cause a brand new problem in such patients, which will require a different and expensive treatment. Therefore, it’s better to prescribe the more costly escitalopram as opposed to a cheaper tricyclic in these patients.
Simplicity of treatment: The best mode of administration is preferred. When there is an alternative between a shot and oral administration, aforementioned is preferred if the efficacy of the two modes is comparable. Or, local application is preferred to the oral route where possible; e.g., antibiotic management of eye infections. Dosage and frequency of administration too are key point to choose simplicity of treatment.
To read more about directory you can check our webpage: click to read more