SINCE Wwii, medical science has progressed to a stage where competitive medications are around for treat precisely the same ailment in several people. This isn’t almost brands (the industry trade issue) but generic drugs (the industry scientific issue). In this report, we shall consider the various factors that decide the selection of a particular drug.
Safety: The following sub-criteria must be considered beneath the criterion of safety:
* Acute therapeutic index: When the patient’s condition is acute, how effective can be a particular drug even if it has certain side-effects provided that the acuteness of the condition is lowered? Example: narcotic pain-killers work well in healing pain but include the possible side-effect of addiction.
* Long-term safety: medicationdirectory.com could be safe in short-term treatment, but wait, how safe it really is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but could have undesirable effects in the event of prolonged use.
* Drug-drug interaction risk: Medicines are chemicals, and a lot of chemicals react to make a different chemical, that have an effect that could harm the person or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to make a new condition that warrants separate treatment.
Drug-drug interaction risk is of two kinds:
· Pharmacokinetic: In this kind of drug-drug interaction, two drugs, independent of the other, have certain effects using one or maybe more body processes (e.g., metabolism) that affects the performance of the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) is dependent upon due to the metabolism. This will cause a boost in the side-effects of Lexapro.
· Pharmacodynamic: Here, 2 or more drugs actually make the same influence on precisely the same organ, thus improving the total, added effect. Example: Lexapro has certain side-effects including drowsiness and fatigue. Darvocet-N also acts similarly about the brain. Thus, the side-effects of both drugs are more intense.
Tolerability: A medicine could be effective but not tolerable by all patients. Example: Allergies to certain drugs in certain people. Short-term and long-term tolerability should be looked at. Efficacy: A medicine isn’t equally great at all patients. For example, some patients with depression or panic disorders experience reduced escitalopram, but there are several that don’t, who therefore should be prescribed an alternative anti-depressant. The rate of oncoming of therapeutic action is a step to be regarded too.
Cost: Cost does not necessarily mean the price tag on acquiring some medicine alone. It should also cover the price tag on treatment of a complication that could arise by using an alternative drug. Example: Within a person who insists on taking alcohol and yet must be treated for depression is often administered an SSRI drug since these drugs don’t potentiate the results of alcohol, whereas another number of anti-depressants (including tricyclics) could cause a whole new overuse injury in such patients, which could require a various and expensive treatment. Therefore, it’s better to prescribe the more expensive escitalopram rather than a cheaper tricyclic such patients.
Simple treatment: The best mode of administration is preferred. If there is a selection between a shot and oral administration, the latter is preferred if your efficacy of both modes can be compared. Or, local application is preferred to the oral route where possible; e.g., antibiotic treatment of eye infections. Dosage and frequency of administration too are a key factor to determine simple treatment.
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