SINCE Wwii, medical science has progressed with a stage where competitive medications are available to treat exactly the same ailment in various people. It’s not just about brands (that is a trade issue) but generic drugs (that is a scientific issue). Within this report, we shall glance at the various factors that decide the selection of a selected drug.
Safety: The following sub-criteria should be considered under the criterion of safety:
* Acute therapeutic index: When the patient’s condition is acute, how effective is really a particular drug even if it has certain side-effects so long as the acuteness with the condition is lowered? Example: narcotic pain-killers are incredible in healing pain but come with the potential side-effect of addiction.
* Long-term safety: medication could be safe in short-term treatment, so how safe it really is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but can have undesirable effects in the event of prolonged use.
* Drug-drug interaction risk: Drugs are chemicals, and several chemicals answer create a different chemical, that have an effect that may harm the sufferer or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to produce a new condition that warrants separate treatment.
Drug-drug interaction risk is of two sorts:
· Pharmacokinetic: In this kind of drug-drug interaction, two drugs, separate from one another, have certain effects on a single or higher body processes (e.g., metabolism) that affects the performance with the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the action of a liver enzyme that Lexapro (escitalopram) depends upon for its metabolism. This causes an increase in the side-effects of Lexapro.
· Pharmacodynamic: Here, 2 or more drugs actually produce the same impact on exactly the same organ, thus increasing the total, added effect. Example: Lexapro has certain side-effects like drowsiness and fatigue. Darvocet-N also acts similarly about the brain. Thus, the side-effects of both the drugs are more intense.
Tolerability: A medicine could be effective however, not tolerable by all patients. Example: Allergies to particular drugs in a few people. Short-term and long-term tolerability should be considered. Efficacy: A medicine just isn’t equally great at all patients. For instance, some patients with depression or anxiety attacks experience respite from escitalopram, but there are lots of that don’t, who therefore should be prescribed a different anti-depressant. The interest rate of oncoming of therapeutic action is a vital key to be regarded too.
Cost: Cost does not necessarily mean the price tag on buying a particular medicine alone. It must also cover the price tag on treating a complication that may arise from using a different drug. Example: In a one who insists on taking alcohol but should be treated for depression is often administered an SSRI drug as these drugs don’t potentiate the end results of alcohol, whereas another number of anti-depressants (like tricyclics) may cause a whole new condition in such patients, which will need a various and expensive treatment. Therefore, it’s better to prescribe the more expensive escitalopram instead of a cheaper tricyclic in such patients.
Simple treatment: The best mode of administration is preferred. If there is a choice between a shot and oral administration, the second is preferred in the event the efficacy of both the modes is comparable. Or, local application is preferred to the oral route where possible; e.g., antibiotic treating eye infections. Dosage and frequency of administration too are a key factor to determine simplicity of treatment.
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