SINCE The second world war, medical science has progressed with a stage where competitive medications are around to treat exactly the same ailment in several people. This isn’t almost brands (that is a trade issue) but generic drugs (that is a scientific issue). With this report, we shall glance at the various factors that decide picking a a particular drug.
Safety: The subsequent sub-criteria has to be considered within the criterion of safety:
* Acute therapeutic index: In the event the patient’s condition is acute, how effective can be a particular drug regardless of whether it’s certain side-effects provided that the acuteness with the condition is lowered? Example: narcotic pain-killers are incredible in healing pain but feature the potential side-effect of addiction.
* Long-term safety: directory could possibly be safe in short-term treatment, but exactly how safe it can be in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but sometimes have undesirable effects in case of prolonged use.
* Drug-drug interaction risk: Medicines are chemicals, and several chemicals respond to develop a different chemical, that have an effect which could harm the person or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to make a new condition that warrants separate treatment.
Drug-drug interaction risk is of two types:
· Pharmacokinetic: In this type of drug-drug interaction, two drugs, outside of the other person, have certain effects using one or more body processes (e.g., metabolism) that affects the performance with the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the action of a liver enzyme that Lexapro (escitalopram) is determined by due to the metabolism. This leads to a rise in the side-effects of Lexapro.
· Pharmacodynamic: Here, two or more drugs actually produce the same effect on exactly the same organ, thus enhancing the total, added effect. Example: Lexapro has certain side-effects including drowsiness and fatigue. Darvocet-N also acts similarly for the brain. Thus, the side-effects of both the drugs are more serious.
Tolerability: A drug could possibly be effective and not tolerable by all patients. Example: Allergies to specific drugs in most people. Short-term and long-term tolerability have to be taken into account. Efficacy: A drug is not equally efficient at all patients. For instance, some patients with depression or anxiety attacks experience respite from escitalopram, but there are several that do not, who therefore have to be prescribed an alternative anti-depressant. The speed of start of therapeutic action is a factor to be considered too.
Cost: Cost doesn’t imply the price of purchase of some medicine alone. It will also cover the price of treating a complication which could arise while using an alternative drug. Example: In a one who insists on taking alcohol but should be treated for depression is often administered an SSRI drug because they drugs don’t potentiate the consequences of alcohol, whereas another group of anti-depressants (including tricyclics) can cause a brand new problem in such patients, which could demand a various and expensive treatment. Therefore, it’s better to prescribe the more costly escitalopram rather than cheaper tricyclic in such patients.
Simplicity of treatment: The easiest mode of administration is preferred. If you have an option between a shot and oral administration, aforementioned is preferred in the event the efficacy of both the modes is analogous. Or, local application is chosen over the oral route where possible; e.g., antibiotic treating eye infections. Dosage and frequency of administration too are an important factor to determine simplicity of treatment.
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