Selective androgen receptor modulators (SARMs) differentially bind to androgen receptors determined by each SARM’s chemical structure. Therefore, SARMs cause anabolic cellular activity while avoiding lots of the side effects of now available steroid drugs. SARMs happen to be studied within the treatments for breast cancers and cachexia and have been used as performance-enhancing agents. Here, we evaluate and summarize the existing literature on SARMs.
Aim
Presenting the background, mechanisms, current and potential clinical applications, along with risks and advantages of SARMs.
Methods
A literature review was performed in MEDLINE while using terms selective androgen receptor modulator, hypogonadism, cachexia, cancers of the breast, benign prostatic hyperplasia, libido, and muscle tissue. Both basic research and clinical tests were included.
Main Outcome Measure
To complete overview of peer-reviewed literature.
Results
However, there are presently no U.S. Food and Drug Agency-approved indications for SARMs, investigators are exploring the potential uses of these compounds. Basic research has focused on the pharmacokinetics and pharmacodynamics of such agents, demonstrating good availability with a paucity of drug interactions. Early scientific studies have demonstrated potential purposes of SARMs inside the management of cancer-related cachexia, benign prostatic hyperplasia (BPH), hypogonadism, and cancers of the breast, with good results.
Conclusion
SARMs have some of possible clinical applications, with promise for the safe use in the treatment of cachexia, BPH, hypogonadism, cancer of the breast, and prostate cancer.
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