Selective androgen receptor modulators (SARMs) differentially bind to androgen receptors based on each SARM’s chemical structure. Therefore, SARMs result in anabolic cellular activity while avoiding many of the negative effects of available steroid drugs. SARMs are already studied from the treatment of cancer of the breast and cachexia and have also been used as performance-enhancing agents. Here, we evaluate and summarize the present literature on SARMs.
Aim
Presenting the setting, mechanisms, current and potential clinical applications, in addition to risks and advantages of SARMs.
Methods
A literature review was performed in MEDLINE using the terms selective androgen receptor modulator, hypogonadism, cachexia, breast cancer, benign prostatic hyperplasia, libido, and lean body mass. Both investigation and studies were included.
Main Outcome Measure
To finish an assessment peer-reviewed literature.
Results
Although there are no U.S. Food and Drug Agency-approved indications for SARMs, investigators are exploring the potential ways to use these compounds. Investigation has devoted to the pharmacokinetics and pharmacodynamics of these agents, demonstrating good availability using a paucity of drug interactions. Early studies have demonstrated potential uses for SARMs inside the treating cancer-related cachexia, benign prostatic hyperplasia (BPH), hypogonadism, and breast cancer, with results.
Conclusion
SARMs have numerous possible clinical applications, with promise for the safe use within the treating cachexia, BPH, hypogonadism, cancer of the breast, and prostate type of cancer.
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