SINCE World War II, medical science has progressed to a stage where competitive medications are for sale to treat the identical ailment in different people. This is simply not pretty much brands (the trade issue) but generic drugs (the scientific issue). With this report, we shall glance at the various factors that decide the selection of a certain drug.
Safety: The following sub-criteria has to be considered underneath the criterion of safety:
* Acute therapeutic index: In the event the patient’s condition is acute, how effective is really a particular drug even when they have certain side-effects providing the acuteness with the condition is lowered? Example: narcotic pain-killers are incredible in healing pain but have the opportunity side-effect of addiction.
* Long-term safety: medication directory might be safe in short-term treatment, but wait, how safe it really is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but tend to have undesirable effects in the event of prolonged use.
* Drug-drug interaction risk: Prescription medication is chemicals, and many chemicals reply to make a different chemical, which has an effect that may harm the individual or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to produce a new condition that warrants separate treatment.
Drug-drug interaction risk is of two kinds:
· Pharmacokinetic: In this kind of drug-drug interaction, two drugs, outside of the other, have certain effects using one or maybe more body processes (e.g., metabolism) that affects the performance with the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the action of a liver enzyme that Lexapro (escitalopram) is dependent upon because of its metabolism. This causes an increase in the side-effects of Lexapro.
· Pharmacodynamic: Here, 2 or more drugs actually create the same impact on the identical organ, thus enhancing the total, added effect. Example: Lexapro has certain side-effects for example drowsiness and fatigue. Darvocet-N also acts similarly around the brain. Thus, the side-effects of the two drugs are more serious.
Tolerability: A medication might be effective however, not tolerable by all patients. Example: Allergies to certain drugs in certain people. Short-term and long-term tolerability need to be considered. Efficacy: A medication is not equally efficient at all patients. As an example, some patients with depression or anxiety attacks experience reduced escitalopram, but there are lots of who don’t, who therefore need to be prescribed another anti-depressant. The rate of onset of therapeutic action is a the answer to be considered too.
Cost: Cost doesn’t imply the price tag on buying some medicine alone. It ought to also cover the price tag on management of a complication that may arise while using another drug. Example: Inside a individual who insists on taking alcohol yet needs to be treated for depression is generally administered an SSRI drug because they drugs don’t potentiate the end results of alcohol, whereas another number of anti-depressants (for example tricyclics) could cause a new symptom in such patients, which may demand a various and expensive treatment. Therefore, it’s safer to prescribe the more expensive escitalopram instead of a cheaper tricyclic in these patients.
Simplicity of treatment: Most effective mode of administration is preferred. If you have a selection between an injection and oral administration, the latter is preferred in the event the efficacy of the two modes can be compared. Or, local application is chosen over the oral route where possible; e.g., antibiotic management of eye infections. Dosage and frequency of administration too are an important factor to decide simple treatment.
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