SINCE World War II, medical science has progressed to a stage where competitive medications are for sale to treat the same ailment in numerous people. This isn’t just about brands (the industry trade issue) but generic drugs (the industry scientific issue). On this report, we shall look at the various factors that decide the selection of a selected drug.
Safety: These sub-criteria should be considered beneath the criterion of safety:
* Acute therapeutic index: In the event the patient’s condition is acute, how effective can be a particular drug even if it’s got certain side-effects providing the acuteness in the condition is lowered? Example: narcotic pain-killers are amazing in healing pain but come with the potential side-effect of addiction.
* Long-term safety: medicine might be safe in short-term treatment, but how safe it really is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but could have undesirable effects in case there is prolonged use.
* Drug-drug interaction risk: Medicine is chemicals, and lots of chemicals answer produce a different chemical, that have an effect that may harm the patient or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to produce a new condition that warrants separate treatment.
Drug-drug interaction risk is of 2 types:
· Pharmacokinetic: In this kind of drug-drug interaction, two drugs, separate from the other person, have certain effects on one or more body processes (e.g., metabolism) that affects the performance in the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) is determined by for the metabolism. This leads to a boost in the side-effects of Lexapro.
· Pharmacodynamic: Here, several drugs actually produce the same impact on the same organ, thus increasing the total, added effect. Example: Lexapro has certain side-effects such as drowsiness and fatigue. Darvocet-N also acts similarly about the brain. Thus, the side-effects of both the medicines are more serious.
Tolerability: A medication might be effective and not tolerable by all patients. Example: Allergies to particular drugs in some people. Short-term and long-term tolerability must be taken into consideration. Efficacy: A medication just isn’t equally great at all patients. As an example, some patients with depression or anxiety disorders experience reduced escitalopram, but there are lots of who don’t, who therefore must be prescribed some other anti-depressant. The rate of start of therapeutic action is a vital the answer to be considered too.
Cost: Cost does not mean the price of acquiring a specific medicine alone. It ought to also cover the price of treatments for a complication that may arise from using some other drug. Example: In the individual that insists on taking alcohol and yet has to be treated for depression is normally administered an SSRI drug because they drugs don’t potentiate the effects of alcohol, whereas another number of anti-depressants (such as tricyclics) could cause a fresh problem in such patients, which may have to have a various and expensive treatment. Therefore, it’s easier to prescribe the more costly escitalopram rather than a cheaper tricyclic such patients.
Simple treatment: The easiest mode of administration is preferred. If you find an option between an injection and oral administration, aforementioned is preferred if your efficacy of both the modes is analogous. Or, local application is preferred to the oral route where possible; e.g., antibiotic treatments for eye infections. Dosage and frequency of administration too are a key factor to determine simple treatment.
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